Mandaluyong continues to celebrate its stature as one of the National Capital Region's foundations of progress. The city serves as the address of the headquarters of the some of the major conglomerates in the country such as the Asian Development Bank, Banco De Oro, San Miguel Corporation, and UNILAB. The New Tiger of Metro Manila, Mandaluyong is one of the leading business and industrial capitals in the Philippines today.

It is strategically located at the center of urban and economic vibrancy in the region, being flanked by equally successful cities, such as Quezon City, Makati, Taguig, and Pasig. A master-planned city, Mandaluyong is touted as one of Metro Manila's finest destination that offers an array of mixed-use developments. Apart from this, the city also plays a huge role in supplying much of Metro Manila's demand for business process outsourcing (BPO) buildings, ranking third in terms of the number of BPO establishments present behind Quezon City and Makati.